Cognitive & Neuroprotection

Pinealon

A CNS trophic peptide positioned for cognitive resilience research.

Last updated 12 August 2026

Studied forCognitive support · Neuroprotection · Stress resilience

Evidence on file1 animal study · 1 citation not yet graded

Strongest sourcePinealon corrects hyperhomocysteinemia-induced disturbances of the diurnal dynamics of hypothalamic norepinep… (animal study)

Mechanism

Oligopeptide regulatory effects on brain tissue.

Reported effects

What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.

Cognitive support
Neuroprotection
Stress resilience

Dosing on file unverified

1-2 mg daily, cycled 2–3 weeks

Reported dose	Volume	Draw
Low — 1 mg	0.2 mL	20 units
High — 2 mg	0.4 mL	40 units

What that assumes. Assumes 10 mg in 2 mL (5000 mcg/mL) drawn on a U-100 barrel — the preset on this record, not a recommendation and not the only way to mix it. Change the vial mass, the diluent or the barrel and every number in this table changes. Run your own.

Carried from a source that labels it unverified, and reproduced with that label attached. A record of what is reported, not a recommendation. No citation on this page establishes it.

Reconstitution

Vial	Diluent	Concentration	Typical dose	Draw
10 mg	2 mL	5000 mcg/mL	1000 mcg	20 units

mass ÷ diluent = concentration; dose ÷ concentration = volume; volume × the syringe factor = units on the barrel (100 for U-100, 40 for U-40). Run your own numbers.

Literature on file 2

animal in vivo
Pinealon corrects hyperhomocysteinemia-induced disturbances of the diurnal dynamics of hypothalamic norepinephrine content in female rats (Neurochemical Journal 2014, cited 3x) graded on: an animal model — “rats”

Not graded

1 citation whose study design could not be read from the title. Left ungraded rather than guessed at.

not graded
Pinealon Increases Cell Viability by Suppression of Free Radical Levels and Activating Proliferative Processes (Rejuvenation Research 2011, cited 12x)

Identity

Space-filling 3D model of Pinealon, carbon grey, nitrogen blue, oxygen red — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

2D chemical structure of Pinealon — Built from the SMILES on this record — the atoms, bonds and stereochemistry are exact. The shape is **one computed low-energy pose**, not a measured structure: a flexible peptide in solution has no single conformation. The skeletal formula below claims connectivity and nothing more, which is what we actually know.

Molecular weight: 418.40
Molecular formula: C15H26N6O8
CAS number: 175175-23-2
PubChem CID: 10273502
InChI key: QPRZKNOOOBWXSU-CIUDSAMLSA-N
Sequence: EDR
SMILES: C(C[C@@H](C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)N)CN=C(N)N
InChI: InChI=1S/C15H26N6O8/c16-7(3-4-10(22)23)12(26)21-9(6-11(24)25)13(27)20-8(14(28)29)2-1-5-19-15(17)18/h7-9H,1-6,16H2,(H,20,27)(H,21,26)(H,22,23)(H,24,25)(H,28,29)(H4,17,18,19)/t7-,8-,9-/m0/s1

Classified as

Subcutaneousroute: This is the route the reconstitution arithmetic assumes. Mass divided by diluent volume gives concentration, dose divided by concentration gives volume, and volume in mL multiplied by 100 gives units on a U-100 barrel: 5 mg in 2 mL is 2.5 mg/mL, and 0.25 mg comes out at 0.1 mL, which is 10 units.
Intranasalroute: A nasal device delivers a fixed volume per spray, so concentration rather than syringe volume sets the amount per spray, and a mass figure on a record is not usable until you know how many actuations it was divided across.
Oralroute: Route sets what a milligram means. An oral figure and an injected figure for the same compound are not comparable amounts, and treating one as the other is one of the commonest ways a record gets misread.

Also called

Pinealon

Notes unverified prose

No large RCTs; small Russian studies; no FDA approval; no validated human dose; Khavinson tradition; preclinical (87%); 2 small human studies

Not on file 0

All 8 tracked fields hold a value on this record: molecular weight and formula, CAS number, PubChem CID, amino-acid sequence, SMILES, InChI and InChI key.

Counted from the record itself, not from what a source said it was missing. 136 of 185 records still have at least one empty.