Snap-8

Mechanism

SNAP-25 is one of three proteins that assemble into the SNARE complex driving vesicle fusion and neurotransmitter release at the neuromuscular junction. Acetyl octapeptide-3 reproduces a short stretch of the SNAP-25 N-terminal region, and the proposed action is competitive interference with SNARE assembly, reducing acetylcholine release and so the contraction that creates expression lines. Peptides copied from other SNARE motifs have inhibited complex formation and exocytosis in cell work; no published experiment demonstrates that action for this sequence specifically.

Reported effects

What sources associate with this compound. Reported categories, not outcomes we have graded — each would need its own citation and rung.

• Claimed reduction in the appearance of expression lines (topical, cosmetic claim)

Half-life, storage & sport

Elimination half-life

not on file — No pharmacokinetic study on file. Skin permeation has not been measured for this peptide in any published work found; the question of whether an eight-residue charged peptide crosses the stratum corneum at all is open, which is why the human studies delivered it by microneedle.

Storage

not on file — no stability record on file — cosmetic-ingredient supplier data only.

In sport (WADA 2026)

not recorded as a yes or no — not named; S0 catch-all if used systemically at all times if S0 applies the list Acetyl octapeptide-3, a cosmetic ingredient. Not named on the list. USADA's cosmetics guidance names several cosmetic peptides as not prohibited but does not name SNAP-8; topical route is not itself an exemption.

Reported adverse effects

No safety study of acetyl octapeptide-3 on its own is on file.

No skin reactions reported in a 12-week study of a microneedle patch containing this peptide among four other actives.

Literature on file 5

• human observational
  Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Having Dual Anti-Wrinkle Effects With Safe and Long-Term Activities (Ann Dermatol 2024;36:213-223) graded on: a clinical evaluation in people, without randomisation stated; the patch is multi-ingredient, so it grades the study design and not an effect of acetyl octapeptide-3 alone — read from the abstract — “abstract review”
• human observational
  Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study (J Cosmet Dermatol 2020;19:1975-1983) graded on: indexed as a clinical trial, design not stated — “Clinical Trial”
• animal in vivo
  Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptor-Derived Peptides for Regulation of Mast Cell Degranulation (Front Immunol 2018;9:725) graded on: an animal model — read from the indexed abstract — “rats”
• review or editorial
  SNARE Modulators and SNARE Mimetic Peptides (Biomolecules 2022;12:1779) graded on: indexed as "review-article" - secondary literature, not a study — “review-article”
• review or editorial
  Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy (Front Chem 2020;8:572923) graded on: indexed as "review-article" - secondary literature, not a study — “review-article”

What is circulated not evidence 3

Claims passed around in community guides and vendor copy, recorded because they circulate — not because they are true. Each is shown with the page it was read from and what this record actually holds. Checked 2026-08-24.

• unverified community data benefit common nothing on file either way

  A wrinkle-depth reduction of up to 63% after 28 days of a 10% solution is circulated in retail copy, sourced to the supplier Lipotec's own 17-person, uncontrolled in-house test.

  63.18% Maximum reduction in wrinkle depth after 28 days of twice-daily application of 10% SNAP-8 solution

  On the record The corpus record states that every peer-reviewed human study naming this peptide tested it inside a multi-ingredient product, so no published result isolates what it does on its own — and its gaps row records isolated_efficacy as absent. A maximum-individual-response figure from an uncontrolled supplier test, restated as a headline result, is exactly the qualification-stripping chain: it starts at Lipotec's brochure and ends as a retail before-and-after claim.

  Source 1

• unverified community data benefit ubiquitous contradicts the record

  SNAP-8 is circulated as "topical Botox" — the most effective topical option for expression lines.

  It's called 'topical Botox' for a reason

  On the record The corpus mechanism row records the proposed SNARE-interference action but states plainly that no published experiment demonstrates that action for this sequence specifically. The mechanism the nickname rests on has never been shown for this peptide.

  Source 1

• unverified community data sourcing fringe nothing on file either way

  Some peptide-community pages now discuss injecting SNAP-8, a route no study of any kind supports.

  Why Not to Inject It

  On the record The corpus holds SNAP-8 as a topical cosmetic ingredient with no reconstitution row and no dosing row; no injectable use of any kind is on file. That vendors sell it as a lyophilised research vial at all is a community artefact.

  Source 1

Identity

Molecular weight

1075.2

Molecular formula

C41H70N16O16S

CAS number

868844-74-0

PubChem CID

76283482

InChI key

KMACPCJUCHVVGP-FNRPHRCSSA-N

Sequence

Ac-EEMQRRAD-NH2

SMILES

C[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)C

InChI

InChI=1S/C41H70N16O16S/c1-19(33(67)57-27(32(43)66)18-31(64)65)50-34(68)21(6-4-15-48-40(44)45)52-35(69)22(7-5-16-49-41(46)47)53-37(71)24(8-11-28(42)59)54-39(73)26(14-17-74-3)56-38(72)25(10-13-30(62)63)55-36(70)23(51-20(2)58)9-12-29(60)61/h19,21-27H,4-18H2,1-3H3,(H2,42,59)(H2,43,66)(H,50,68)(H,51,58)(H,52,69)(H,53,71)(H,54,73)(H,55,70)(H,56,72)(H,57,67)(H,60,61)(H,62,63)(H,64,65)(H4,44,45,48)(H4,46,47,49)/t19-,21-,22-,23-,24-,25-,26-,27-/m0/s1

Also called

• Acetyl Octapeptide-3
• Snap-8
• Acetyl Glutamyl Heptapeptide-3
• Acetyl Octapeptide-8

Listed prices 119

What 84 shops we track listed for Snap-8, read from their own public catalogues on 2026-09-14. We take no commission on these and they are not ranked by any payment — how vendors are scored.